What is PRP?
PRP is an autologous (comes from your body) biologic derived from whole blood that is preferentially enriched with platelets and growth factors. This is performed by drawing a portion of your own blood and separating it into two parts; whole red blood cells and plasma enriched with platelets, clotting factors, and white blood cells. This Plasma is a commonly used therapy to accelerate the healing of injured tendons, ligaments, muscles and joints. It is secondarily used for skin rejuvenation, hair loss, and wound repair.
While platelets are the primary component of PRP, preparations will also contain other cellular components such as white blood cells (WBCs) and peripheral stem cells. These components all play a biological role in the healing process and are provided at concentrated levels in PRP preparation process. Thus, PRP may help optimize the conditions for healing of bone and soft tissue.
Platelets – Platelets play a critical role in several aspects of the healing process. Activated platelets express adhesion molecules that support clot formation for hemostasis. They also release several antimicrobial peptides that deliver properties for infection control. Most importantly as it relates to healing, platelets also release chemokines and numerous growth factors, including SDF-1α (directs stems cells to site of injury), PDGF(attracts stem cells and endothelial cells), TGF-β (Growth factor promoting tissue growth) and VEGF(Stimulates blood vessel growth and bone formation), these factors have been shown to orchestrate key biological processes, including angiogenesis, inflammation resolution and tissue regeneration.
How It Works -The concept behind the clinical use of PRP is to harness the natural biological components of a patient’s blood―primarily platelets―which may help optimize the conditions for healing, improve inflammatory response, control infection and promote angiogenesis.
Platelets facilitate healing through release of many growth factors actively involved in this process. Thus, PRP offers the physician an alternative to other widespread options, such as steroid or hyaluronic acid injections that provide short-term relief by masking symptoms such as pain and inflammation that are the result of an injury, rather than actually addressing the cause of the injury directly through repair of damaged tissue.
Commonly used applications – Because of PRP’s ability to optimize the conditions of bone and soft tissue healing, it is commonly used in the following applications:
– Orthopedics & Sport Medicine
– Pain Rehabilitation & Pain Management
– Cosmetic & Aesthetic Medicine
– Oral & Maxillofacial Surgery